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老師姓名: 王錫五 |
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職稱:教授 |
研究室： 內分泌實驗室 |
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最高學歷：Ph.D. |
學校/國家：美國 |
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分機號碼：5253 |
電子郵件帳號： swwang@mail.cgu.edu.tw |
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個人網頁網址： |
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研究室現況: |
博士後研究員 人 |
博士班研究生 人 |
碩士班研究生4 人 |
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專任研究助理 1人 |
大學部專題生1 人 |
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研究方向及研究室特色：
內分泌實驗室位於醫學大樓八樓醫學生物共同研究室的一角，共同研究室係由六位不同研究領域的老師組成，包括藥理、生化、解剖及生理方面。本實驗室除在開放的空間擁有三個實驗檯外，尚有細胞培養室、放射線操作室及共用之儀器室，並與解剖科莊宏亨老師實驗室互動，進行分生方面的研究；亦與醫院皮膚科及醫美主治醫師胡倩婷合作。本實驗室主要的研究主題為：
食物中的營養成分對於人體內分泌及免疫細胞功能之作用機制
此類營養成分有來自蕃茄的茄紅素，茶葉的兒茶素，辣椒中的蕃椒辣素等小分子，觀察這些營養物對：
(1) 人血中免疫細胞(如：淋巴球、單核球)分泌細胞素(Cytokines)的影響。
(2) 內分泌系統(大鼠卵巢、睪丸、腎上腺)荷爾蒙分泌之影響。
(3) 腎癌細胞RCC分泌細胞素及生長之影響。
(4) 皮膚癌(melanoma)細胞生長之影響。
中藥及藥物對免疫或內分泌之作用
以市面上常見之中藥，如「甘草素」、「黃蓮」、「雷公藤」、或救心的成分「毛地黃」為主，觀察其對內分泌腺體分泌荷爾蒙、腎癌細胞RCC、皮膚癌(melanoma)細胞、及免疫細胞分泌細胞素之影響。
最近五年所發表論文、著作及專利: (2013-2017)
1. Wang KL, Hsia SM, Yeh JY, Cheng SC, Wang PS*, and Wang SW*. Anti-Proliferative Effects of Evodiamine on Human Breast Cancer Cells. PLoS ONE 2013. 8(6): e67297.
(I.F.2.806 Rank:15/64=23.438% Field: Multidisciplinary Sciences)
2. Tsui KH, Wang SW, Chung LC, Feng TH, Lee TY, Chang PL, and Juang HH*. Mechanisms by Which Interleukin-6 Attenuates Cell Invasion and Tumorigenesis in Human Bladder Carcinoma Cells. BioMed Research International. (Journal of Biomedicine and Biotechnology) 2013 Article ID 791212,
(I.F.:2.476, Rank:67/160=41.875% Field: BIOTECHNOLOGY & APPLIED MICROBIOLOGY)
(I.F.:2.476, Rank:65/128=50.781% Field: MEDICINE, RESEARCH & EXPERIMENTAL)
3. Tsui KH, Chung LC, Wang SW, Feng TH, Chang PL, and Juang HH*. Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells. J Mol Endocrinol. 2013; 51, 131–141.
(I.F.:3.577, Rank:53/138=38.406%, Field: ENDOCRINOLOGY & METABOLISM)
4. Hwang GS, Hu S, Lin YH, Chen ST, Tang TK Wang PS, Wang. SW*. Arecoline inhibits interleukin-2 secretion in Jurkat cells by decreasing the expression of alpha7-nicotinic acetylcholine receptors and prostaglandin E2. J Physiol Pharmacol. 2013; 64(10), 535-543.
(I.F.:2.883 Rank:29/84=34.523% Field: Physiology)
5. Lieu FK, Lin CY, Wang PS, Jian CY, Yeh YH, Chen YA, Wang KL, Lin YC, Chang LL, Wang GJ, Wang SW*. Effect of swimming on the production of aldosterone in rats. PLOS ONE 2014, Oct, 9:e87080.
(I.F.2.806 Rank:15/64=23.438% Field: MULTIDISCIPLINARY SCIENCES)
6. Chang YJ, Hwu CM, Yeh CC, Wang PS*, Wang SW*. Effects of subacute hypothyroidism on metabolism and growth-related molecules. Molecules 2014. 19(8):11178-11195.
(I.F.2.861 Rank:17/59=28.814% Field: CHEMISTRY, ORGANIC)
7. Wang ZH, Hsu HW, Chou JC, Yu CH, Bau DT, Wang GJ, Huang CY, Wang PS*, and Wang SW*. Cytotoxic Effect of S-Petasin and Iso-S-Petasin on the Proliferation of Human Prostate Cancer Cells. Anticancer Res. 2015, Jan, 35: 191-200.
(I.F.=1.937 Rank:161/217=74.194% Field: Oncology)
8. Sindy Hu, Wen-Chyuan Chen, Guey-Shyang Hwang, Szu-Tah Chen, Song-Bor Kuo, Yifen Chen, Galina Idova, Shyi-Wu Wang*. Changes in plasma steroids and cytokines levels in betel chewing patients in Taiwan. Steroids 2016, July,111:134-138.
(I.F.=2.282 Rank: 186/290 = 64.138 % Field:Biochemistry )
(I.F.=2.282, Rank: 95/138 = 68.84 % Field:Endocrinology/Metabolism)
9. Chen CW, Jian CY, Lin PH, Chen CC, Lieu FK, Soong C, Hsieh CC, Wan CY, Idova G, Hu S, Wang SW*, and Wang PS*. Role of testosterone in regulating induction of TNF-a in rat spleen via ERK signaling pathway. Steroid, 2016, July, 111: 148-154.
(I.F.=2.282 Rank: 186/290 = 64.138 % Field:Biochemistry )
(I.F.=2.282, Rank: 95/138 = 68.84 % Field:Endocrinology/Metabolism)
10. Wang KL, Huang WC, Chou JC, Ting-Chun Weng TC, Sindy Hu S, Fu-Kong Lieu FK, Wei-Ho Lai WH, Idova G, Wang PS*, Wang SW*. Effects of acrolein on aldosterone release from zona glomerulosa cells in male rats. Steroids, 2016, July,111:89-94.
(I.F.=2.282 Rank: 186/290 = 64.138 % Field:Biochemistry )
(I.F.=2.282, Rank: 95/138 = 68.84 % Field:Endocrinology/Metabolism)
11. Yeh YH, Chou JC, Weng TC, Lieu FK, Lin JY, Yeh CC, Hu S, Wang PS*, Idova G, and Wang SW*. Effects of acrolein on the production of corticosterone in male rats. Steroids 2016, July,111:139-147.
(I.F.=2.282 Rank: 186/290 = 64.138 % Field:Biochemistry )
(I.F.=2.282, Rank: 95/138 = 68.84 % Field:Endocrinology/Metabolism)
12. Lin PH, Jian CY, Chou JC, Chen CW, Chen CC, Soong C, Hu S, Lieu FK*, Wang PS*, and Wang SW*. Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats. Sci. Reports 2016, Aug., 6:32085
(I.F.=4.259 Rank: 10/64 = 15.625 % Field: Multidisciplinary Sci )
13. Chen CW, Chen CC, Jian CY, Lin PH, Chou JC, Teng HS, Hu S, Lieu FK*, Wang PS*, and Wang SW*. Attenuation of exercise effect on inflammatory responses via novel role of TLR4/PI3K/Akt signaling in rat splenocytes. J Appl Physiol. 2016, Oct., 121: 870–877.
(I.F.=3.351 Rank: 8/81 = 9.877 % Field: Sport Science)
14. Chen CC, Chen CW, Lin PH, Chou JC, Weng TC, Jian CY, Hu S, Lai WH, Lieu FK*, Wang SW*, and Wang PS*. Interactive Effect of Corticosterone and Lactate on Regulation of Testosterone Production in Rat Leydig Cells. Journal of Cellular Physiology 2017, Aug, 232: 2135–2144
(I.F.=4.080 Rank: 16/84 = 19.05 % Field: physiology)
(I.F.=4.080 Rank: 68/190 = 35.79 % Field: cell biology)
15. Hwang GS, Chen CC, Chou JC, Chang LL, Kan SF, Lai WH, Lieu FK, Hu S, Wang PS, Wang SW*. Stimulatory effect of intermittent hypoxia on the production of corticosterone by zona fasciculata-reticularis cells in rats. Sci Reports, 2017 Aug, 7:9035.
(I.F.=4.259 Rank: 10/64 = 15.625 % Field:Multidisciplinary Sci )
